background:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
Subunit:
Interacts with HOOK1. Part of a large heterooligomeric complex together with VPS11, VPS16 and VPS33A. Interacts with STX7.
Subcellular Location:
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Tissue Specificity:
Ubiquitous. Expression was highest in heart and low in lung.
Similarity:
Belongs to the VPS18 family.
Contains 1 clathrin repeat.
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 57617 Human
Entrez Gene: 228545 Mouse
Entrez Gene: 296083 Rat
Omim: 608551 Human
SwissProt: Q9P253 Human
SwissProt: Q8R307 Mouse
Unigene: 23876 Human
Unigene: 294761 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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