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Rabbit Anti-VAMP3/FITC Conjugated antibody
background:
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008].
Function:
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
Subcellular Location:
Membrane; Single-pass type IV membrane protein (Probable). Cell junction, synapse, synaptosome.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the synaptobrevin family.
Contains 1 v-SNARE coiled-coil homology domain.
Database links:
Entrez Gene: 9341 Human
Entrez Gene: 22319 Mouse
Entrez Gene: 29528 Rat
Omim: 603657 Human
SwissProt: Q15836 Human
SwissProt: Q6FGG2 Human
SwissProt: Q9BRV4 Human
SwissProt: P63024 Mouse
SwissProt: P63025 Rat
Unigene: 66708 Human
Unigene: 273930 Mouse
Unigene: 162135 Rat
Unigene: 219999 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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