Home
>
Product
>
Antibody
>
Rabbit Anti-RAMP1/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the RAMP family of single transmembrane domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin receptor like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.
Function:
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.
Subunit:
Heterodimer of CALCRL and RAMP1.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.
Similarity:
Belongs to the RAMP family.
Database links:
Entrez Gene: 10267 Human
Entrez Gene: 5361 Mouse
Entrez Gene: 58965 Rat
Omim: 605153 Human
SwissProt: O60894 Human
SwissProt: Q9WTJ5 Mouse
SwissProt: Q9JJ74 Rat
Unigene: 471783 Human
Unigene: 3272 Mouse
Unigene: 12265 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|