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Rabbit Anti-Annexin IV/FITC Conjugated antibody
background:
The Annexins are a family of structurally similar proteins. Annexins bind to phospholipids and may be involved in regulation of membrane transport, membrane channel activity, and interaction of the cell membrane with the extracellular matrix. Annexin A4 (ANXA4) belongs to the annexin family of calcium dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane related events along exocytotic and endocytotic pathways. ANXA4 has 45 to 59% identity with other members of its family and shares a similar size and exon intron organization. Isolated from human placenta, ANXA4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANXA4 is almost exclusively expressed in epithelial cells.
Function:
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
Similarity:
Belongs to the annexin family.
Contains 4 annexin repeats.
Database links:
Entrez Gene: 281625 Cow
Entrez Gene: 606756 Dog
Entrez Gene: 307 Human
Entrez Gene: 11746 Mouse
Entrez Gene: 79124 Rat
Omim: 106491 Human
SwissProt: P13214 Cow
SwissProt: P50994 Dog
SwissProt: P09525 Human
SwissProt: P97429 Mouse
SwissProt: P08132 Pig
SwissProt: P55260 Rat
Unigene: 422986 Human
Unigene: 259702 Mouse
Unigene: 19270 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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