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Rabbit Anti-PAI1/FITC Conjugated antibody
background:
PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.
Function:
Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
Subunit:
Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation.
Subcellular Location:
Secreted
Tissue Specificity:
Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells
Post-translational modifications:
Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.
DISEASE:
Plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:613329]: A hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen. Note=The disease is caused by mutations affecting the gene represented in this entry.
Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.
Similarity:
Belongs to the serpin family
Database links:
Entrez Gene: 5054 Human
Entrez Gene: 18787 Mouse
Entrez Gene: 396945 Pig
Entrez Gene: 24617 Rat
Omim: 17372 Human
SwissProt: P13909 Cow
SwissProt: P05121 Human
SwissProt: P22777 Mouse
SwissProt: P79335 Pig
SwissProt: P20961 Rat
Unigene: 414795 Human
Unigene: 713079 Human
Unigene: 250422 Mouse
Unigene: 29367 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PAI-1是一种单链糖蛋白，其生理作用很多：
（1）与组织型纤溶酶原激活物（tissue plasminogen activator，t-PA）形成1：1的复合物而使t-PA失活;
（2）保护基底膜不被血浆来源的酶所降解;
（3）保护细胞间的接触面而维持组织结构的完整性;
（4）在结缔组织演变、凝血、纤溶、补体激活和炎症反应等过程中具有抑制蛋白降解作用;
（5）在细胞周期中，PAI-1转录水平的变化及其在细胞内的积聚，对细胞形态的维持、细胞与其间质的粘附、细胞增殖、信号转导及基因表达等都有重要意义;
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