Rabbit Anti-ALR/FITC Conjugated antibody

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Augmenter of Liver Regeneration; ERV1 homolog; GFER; Growth factor erv1 like; hERV; HERV1; HPO.

Cat:

SL1576R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human ALR C-terminus

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

18kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). Also known as: augmenter of liver regeneration; ERV1 homolog; GFER; Growth factor erv1 like; hERV; HERV1; HPO.

Function:
Isoform 1: FAD-dependent sulfhydryl oxidase. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs.
Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.

Subcellular Location:
Mitochondrion intermembrane space and Cytoplasm. Secreted.

Tissue Specificity:
Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle.

DISEASE:
Defects in GFER are a cause of mitochondrial progressive myopathy with congenital cataract hearing loss and developmental delay (MPMCHD) [MIM:613076]; also called combined mitochondrial complex deficiency.

Similarity:
Contains 1 ERV/ALR sulfhydryl oxidase domain.

Database links:

Entrez Gene: 2671 Human

Entrez Gene: 11692 Mouse

Omim: 600924 Human

SwissProt: P55789 Human

SwissProt: P56213 Mouse

Unigene: 726325 Human

Unigene: 28124 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ALR是近年来发现的一种促肝细胞再生的细胞因子。ALR的生物学作用主要表现在直接刺激肝细胞增殖和再生、对肝脏的保护作用、参与组织器官的形成与发育、免疫调控作用以及促肝癌细胞增殖等效应。s虽然肝再生增强因子有着重要生物学作用,但ALR究竟如何发挥生物学的调节机制，目前还不清楚

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