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Rabbit Anti-CD46/FITC Conjugated antibody
background:
CD46 is one of the membrane complement regulatory proteins. CD46 possesses C3b-binding and factor I cofactor activities which play important roles in the regulation of the complement activation pathway. CD46 is widely distributed on blood cells, endothelial cells, epithelial cells and tumor cell lines. CD46 exists as many isoforms in a variety of tissues. The antigen has a broad distribution and is present on leukocytes, platelets, endothelial cells, epithelial cells and fibroblasts. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. It is expressed on thymocytes, B cells, monocytes, granulocytes, NK cells, platelets, epithelial and endothelial cells.
Function:
May be involved in the fusion of the spermatozoa with the oocyte during fertilization.
Subcellular Location:
Isoform 1: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa.
Isoform 2: Secreted (Probable).
Tissue Specificity:
Present only in testis (at protein level).
Post-translational modifications:
May be O-glycosylated (By similarity).
N-glycosylated.
Similarity:
Contains 4 Sushi (CCP/SCR) domains.
Database links:
Entrez Gene: 17221 Mouse
Entrez Gene: 4179 Human
Entrez Gene: 29333 Rat
Omim: 120920 Human
SwissProt: P15529 Human
SwissProt: O88174 Mouse
SwissProt: Q9Z0M4 Rat
Unigene: 510402 Human
Unigene: 12884 Mouse
Unigene: 163242 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MCP为一单链穿膜糖蛋白,是补体系统的一种新的调节蛋白，是内源性辅助因子活性蛋白属于RCA基因簇的成员。CD46通过GPI锚固定于细胞上。MCP的细胞分布广范，在粒细胞、血小板、T细胞（Th、Ts、Tc）、B细胞、NK细胞、造血细胞系、成纤维细胞、表皮细胞、内皮细胞及星状胶质细胞等都有分布。
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