background:
Aquaporin 1 is a 28kD integral membrane protein which was originally identified in red blood cells and renal proximal tubules. AQP1 is also expressed by the choroid plexus and various other tissues. It forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Function:
Forms a water-specific channel that provides the plasmamembranes of red cells and kidney proximal tubules with highpermeability to water, thereby permitting water to move in thedirection of an osmotic gradient.
Subunit:
Homotetramer. Interacts with EPHB2; involved in endolymphproduction in the inner ear (By similarity).
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.
Similarity:
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Database links:
Entrez Gene: 358 Human
Entrez Gene: 11826 Mouse
Entrez Gene: 2548 Rat
Entrez Gene: 442999 Sheep
Entrez Gene: 282653 Cow
Entrez Gene: 403732 Dog
Omim: 107776 Human
SwissProt: P47865 Cow
SwissProt: Q9N2J4 Dog
SwissProt: P29972 Human
SwissProt: Q02013 Mouse
SwissProt: P29975 Rat
SwissProt: P51281 Sheep
Unigene: 76152 Human
Unigene: 18625 Mouse
Unigene: 1618 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
通道蛋白(Channel Protein)
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