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Rabbit Anti-CXCL10/IP10/FITC Conjugated antibody
background:
Interferon-gamma-inducible 10 kD protein (IP-10), is a CXC chemokine with chemoattractant properties for CD4-positive T cells and inhibits early normal and leukemic hemopoietic progenitor proliferation. IP-10 is produced by a wide variety of cell types ranging from neutrophils and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV encephalitis, cutaneous T cell lymphoma, chronic hepatitis and acute anterior uveitis. Various observations strongly suggest a role for the CXC chemokines IL-8 and IP-10 in the regulation of angiogenic activity in cancer and in idiopathic pulmonary fibrosis.
Function:
Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
Subcellular Location:
Secreted.
Post-translational modifications:
CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.
Similarity:
Belongs to the intercrine alpha (chemokine CxC) family.
Database links:
Entrez Gene: 3627
Human
Entrez Gene: 15945 Mouse
Entrez Gene: 245920 Rat
Omim: 147310 Human
SwissProt: P02778 Human
SwissProt: P17515 Mouse
SwissProt: P48973 Rat
Unigene: 632586 Human
Unigene: 877 Mouse
Unigene: 10584 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
取消WB; 2017.4.20; 姬;
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