background:
The PAF receptor binds platelet-activating factor (PAF) and is thought to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. PAF is a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. It has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.
The PAF receptor is induced by granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-5 and n-butyrate. A diverse range of compounds act as PAF receptor antagonists; these may be useful pharmacologically.
Function:
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
Subunit:
Interacts with ARRB1.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 5724 Human
Entrez Gene: 19204 Mouse
Entrez Gene: 58949 Rat
Omim: 173393 Human
SwissProt: P25105 Human
SwissProt: Q62035 Mouse
SwissProt: Q9XSD4 Pig
SwissProt: P9202 Rat
SwissProt: P35366 Rhesus monkey
Unigene: 433540 Human
Unigene: 725944 Human
Unigene: 89389 Mouse
Unigene: 10137 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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