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Rabbit Anti-AVPR2/FITC Conjugated antibody
background:
This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]
Function:
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Kidney.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Vasopressin/oxytocin receptor subfamily.
Database links:
Entrez Gene: 554 Human
Entrez Gene: 2400 Mouse
Entrez Gene: 25108 Rat
Omim: 300538 Human
SwissProt: P30518 Human
SwissProt: O88721 Mouse
SwissProt: Q00788 Rat
Unigene: 56748 Human
Unigene: 383171 Mouse
Unigene: 209041 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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