Rabbit Anti-LIFR/FITC Conjugated antibody

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CD 118; leukemia inhibitory factor receptor; SWS; SJS2; STWS; CD118; LIF-R; FLJ98106; FLJ99923; LIFR; Leukemia inhibitory factor receptor alpha; LIF R; LIF receptor; LIFR_RAT.

Cat:

SL1458R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Dog,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from the middle of rat LIFR

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

Flow-Cyt=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

117kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.

Function:
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity).

Subunit:
"Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 6 fibronectin type-III domains.

Database links:

Entrez Gene: 3977 Human

Entrez Gene: 16176 Mouse

Entrez Gene: 8336 Rat

Omim: 151443 Human

SwissProt: P42702 Human

SwissProt: P42703 Mouse

SwissProt: O70535 Rat

Unigene: 133421 Human

Unigene: 149720 Mouse

Unigene: 14529 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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