Home
>
Product
>
Antibody
>
Rabbit Anti-Wnt1/FITC Conjugated antibody
background:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.
Function:
Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.
Subunit:
Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3 (By similarity). Interacts with WLS (By similarity).
Subcellular Location:
Secreted, extracellular space, extracellular matrix.
Post-translational modifications:
Palmitoylation at Ser-224 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-93. Palmitoylation is necessary for proper trafficking to cell surface.
Similarity:
Belongs to the Wnt family.
Database links:
Entrez Gene: 7471 Human
Entrez Gene: 2488 Mouse
Entrez Gene: 24881 Rat
Omim: 164820 Human
SwissProt: P04628 Human
SwissProt: P04426 Mouse
Unigene: 248164 Human
Unigene: 1123 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Wnt1是Wnt家族的成员之一,对神经干细胞的增殖及分化有一定的调控作用,Wnt1a蛋白可以促进神经干细胞向神经元分化.
|
|
