Rabbit Anti-Claudin 1/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-Claudin 1/FITC Conjugated antibody

claudin; Claudin1; CLD 1; CLD1; CLDN 1; CLDN1; ILVASC; SEMP 1; SEMP1; Senescence associated epithelial membrane protein 1; Senescence associated epithelial membrane protein; CLD1_HUMAN.

Cat:

SL1428R-FITC

Species Reactivity：

Human,Mouse,Rat,

Immunogen：

KLH conjugated synthetic peptide derived from mouse Claudin 1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

Flow-Cyt=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

23kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq].

Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Subunit:
Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL.

Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed, with highest levels in liver and kidney.

Similarity:
Belongs to the claudin family.

Database links:

Entrez Gene: 9076 Human

Entrez Gene: 12737 Mouse

Entrez Gene: 65129 Rat

Omim: 603718 Human

SwissProt: O95832 Human

SwissProt: O88551 Mouse

SwissProt: P56745 Rat

Unigene: 439060 Human

Unigene: 289441 Mouse

Unigene: 24293 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Claudin 1蛋白是紧密连接区相关的转膜蛋白Claudin的家族成员，在构成紧密连接的完整膜蛋白中发挥着一定作用，目前多用于肿瘤方面的研究。

Product Feedback Wall