background:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq].
Function:
May be involved in MAPK pathways.
Subunit:
Interacts with DDB1-CUL4A/B E3 ligase complexes.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Broadly expressed, with highest levels in heart and skeletal muscle.
Similarity:
Contains 1 CTLH domain.
Contains 1 LisH domain.
Contains 6 WD repeats.
Database links:
Entrez Gene: 80232 Human
Entrez Gene: 226757 Mouse
Entrez Gene: 498301 Rat
SwissProt: Q9H7D7 Human
SwissProt: Q8C6G8 Mouse
Unigene: 497873 Human
Unigene: 289082 Mouse
Unigene: 23078 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
WDR26可能具有通过MAPK信号途径调节细胞增殖的功能。
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