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Rabbit Anti-RGS2/FITC Conjugated antibody
background:
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq].
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Subunit:
Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).
Subcellular Location:
Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Isoform 4: Cell membrane. Mitochondrion.
Tissue Specificity:
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
Post-translational modifications:
Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
Similarity:
Contains 1 RGS domain.
Database links:
Entrez Gene: 5997 Human
Entrez Gene: 19735 Mouse
Entrez Gene: 84583 Rat
Omim: 600861 Human
SwissProt: P41220 Human
SwissProt: O08849 Mouse
SwissProt: Q9JHX0 Rat
Unigene: 78944 Human
Unigene: 28262 Mouse
Unigene: 1892 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白信号转导调节子2(RGS2)是动物机体中神经、激素及外界信号刺激转导的重要信号分子,它作为G蛋白分子开关,在广泛地协调胞外刺激应答中起着重要的作用。
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