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Rabbit Anti-Macrophage Inflammatory Protein 3 alpha/FITC Conjugated antibody
background:
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].
Function:
Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. SLCterminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213.
Subunit:
Binds to and activate CCR6.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.
Post-translational modifications:
SLCterminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
Database links:
Entrez Gene: 6364 Human
Entrez Gene: 20297 Mouse
Entrez Gene: 29538 Rat
Omim: 601960 Human
SwissProt: P78556 Human
SwissProt: O89093 Mouse
SwissProt: P97884 Rat
Unigene: 75498 Human
Unigene: 116739 Mouse
Unigene: 10722 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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