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Rabbit Anti-TRIM32/FITC Conjugated antibody
background:
Tripartite motif-containing protein 32 (TRIM32) belongs to the tripartite motif (TRIM) protein family. TRIM32, like all TRIM proteins, contains a domain structure composed of a B-box, a RING-finger and a coiled-coil motif. Additionally, TRIM32 has six SLCterminal NHL domains; it is expressed mainly in the skeletal muscle. The TRIM32 gene encodes an E3 ubiquitin ligase, a protein that attaches ubiquitin to a lysine residue on a target protein and acts in conjunction with ubiquitin-conjugating enzymes UbcH5a, UbcH5c and UbcH6. Mutations in the TRIM32 gene cause two forms of autosomal recessive muscular dystrophy designated limb girdle muscular dystrophy type 2H (LGMD2H) and sarcotubular myopathy (STM). TRIM32 mutations can also result in Bardet-Biedl syndrome (BBS), an autosomal recessive disorder characterized by pigmentary retinopathy, polydactyly, hypogenitalism, renal abnormalities, learning disabilities and obesity.
Function:
Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) (By similarity). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha.
Subunit:
Interacts with DTNBP1 (By similarity). It self-associates (By similarity). Interacts with PIAS4/PIASY upon treatment with UVB and TNF-alpha.
Subcellular Location:
Cytoplasm. Note=Localized in cytoplasmic bodies, usually concentrated around the nucleus
Tissue Specificity:
Ubiquitous. High expression in brain.
Post-translational modifications:
Ubiquitinated.
Similarity:
Belongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 5 NHL repeats.
Contains 1 RING-type zinc finger
Database links:
Entrez Gene: 22954 Human
Entrez Gene: 61967 Mouse
Omim: 602290 Human
SwissProt: Q13049 Human
SwissProt: Q8CH72 Mouse
Unigene: 591910 Human
Unigene: 22786 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TRIM32蛋白质的表达能促进神经干细胞生成神经元
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