background:
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets. [provided by RefSeq, Jul 2008]
Function:
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).
Subunit:
Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5.
Subcellular Location:
Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.
Tissue Specificity:
High expression in heart and brain.
Post-translational modifications:
Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.
Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Contains 1 protein kinase domain.
Database links:
Entrez Gene: 5596 Human
Entrez Gene: 225724 Mouse
Entrez Gene: 54268 Rat
Omim: 176949 Human
SwissProt: P31152 Human
SwissProt: Q6P5G0 Mouse
SwissProt: Q63454 Rat
Unigene: 433728 Human
Unigene: 254517 Mouse
Unigene: 146899 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MAP kinase 4(MAPK4)也是MAPK家族成员,具有丝/苏氨酸激酶活性。参与细胞生长、增殖、分化、死亡及细胞间的功能同步等多种生理过程,能够被诸如细胞因子、生长因子、神经递质、激素、细胞应急以及细胞粘附等各种刺激因素激活为信号传导途中重要的蛋白激酶,MAPK家族成员之间有很高的同源性。
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