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Rabbit Anti-NRF1/FITC Conjugated antibody
background:
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]
Function:
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Subunit:
Homodimer. Binds DNA as a dimer. Interacts with PPRC1.
Subcellular Location:
Nucleus
Tissue Specificity:
Ubiquitously expressed with strongest expression in skeletal muscle.
Post-translational modifications:
Phosphorylation enhances DNA binding.
Similarity:
Belongs to the NRF1/Ewg family.
Database links:
Entrez Gene: 4899 Human
Omim: 600879 Human
SwissProt: Q16656 Human
Unigene: 654363 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NRF-1是核基因编码且影响mtDNA的另一重要因子, 他控制着线粒体电子传递链的一些蛋白质的合成。
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