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Rabbit Anti-PAG608/FITC Conjugated antibody
background:
This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid.
Function:
Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.
Subunit:
Interacts with dsRNA.
Subcellular Location:
Nucleus. Nucleus, nucleolus.
Tissue Specificity:
Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.
Similarity:
Contains 3 matrin-type zinc fingers.
Database links:
Entrez Gene: 538512 Cow
Entrez Gene: 64393 Human
Entrez Gene: 2481 Mouse
Entrez Gene: 64394 Rat
Omim: 606452 Human
SwissProt: Q0IIC4 Cow
SwissProt: Q9HA38 Human
SwissProt: O54836 Mouse
SwissProt: O08781 Rat
Unigene: 371609 Human
Unigene: 35705 Mouse
Unigene: 2925 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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