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Rabbit Anti-FGF10/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
Subunit:
Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.
Subcellular Location:
Secreted (Potential).
DISEASE:
Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:36920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
Defects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.
Similarity:
Belongs to the heparin-binding growth factors family.
Database links:
Entrez Gene: 2255 Human
Entrez Gene: 14165 Mouse
Entrez Gene: 25443 Rat
Omim: 602115 Human
SwissProt: O15520 Human
SwissProt: O35565 Mouse
SwissProt: P70492 Rat
Unigene: 664499 Human
Unigene: 317323 Mouse
Unigene: 44439 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FGF-10对于角质形成细胞的异常增殖和分化异常可能有着重要的调节作用。有学者认为；部分肿瘤、胚胎发育紊乱、生长发育障碍性疾病、炎症及修复异常、免疫性疾病、血液病、HIV感染等都与FGF-10有关。
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