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Rabbit Anti-PDGFBB/FITC Conjugated antibody
background:
Platelet Derived Growth Factor (PDGF) is the major serum mitogen for cells of mesenchymal origin in humans. The biologically active protein is a dimer composed of two related polypeptides designated A and B, the dimers being connected by disulfide bonds. The PDGF protein has been implicated both directly as well as indirectly in several pathological states including neoplasia, arthritis, arteriosclerosis and bone marrow sclerosis.
Function:
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA.
Subunit:
Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1.
Subcellular Location:
Secreted. Note=Released by platelets upon wounding.
Tissue Specificity:
Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
DISEASE:
Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.
Similarity:
Belongs to the PDGF/VEGF growth factor family.
Database links:
Entrez Gene: 5155 Human
Entrez Gene: 18591 Mouse
Entrez Gene: 24628 Rat
Omim: 190040 Human
SwissProt: P01127 Human
SwissProt: P3148 Mouse
SwissProt: Q05028 Rat
Unigene: 1976 Human
Unigene: 18889 Mouse
Unigene: 198230 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
生长因子和激素( Growth Factor and Hormones)
血小板源性生长因子(PDGF),是由A、B两条多肽链通过二硫键连接而成的同型或异型二聚体。包括三种形式:PDGF-AA、PDGF-BB、PDGF-AB.分子量为28~35KD。
PDGF-BB也是PDGF家族成员,是一种碱性蛋白,可促进细胞分裂并促进神经元的生长, PDGF-BB的正常表达对于神经系统的发育和成熟起着一定的作用。
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