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Rabbit Anti-Integrin Alpha V + Beta 3 (CD51+CD61)/FITC Conjugated antibody
background:
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. They are known to participate in cell adhesion as well as cell-surface mediated signalling. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.
CD51 encodes integrin alpha chain V. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. The CD61 protein product is the integrin beta chain beta 3. Integrin beta 3 is found along with the alpha IIb chain in platelets.
Integrin alpha V/beta 3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha V/beta 3 recognizes the sequence R-G-D in a wide array of ligands. The alpha V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands.
Subcellular Location:
Cell Membrane; single-pass type I membrane protein.
Database links:
Entrez Gene: 3685 Human
Entrez Gene: 3690 Human
Omim: 173470 Human
Omim: 193210 Human
SwissProt: P05106 Human
SwissProt: P06756 Human
Unigene: 23640 Human
Unigene: 436873 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
整合素αVβ3为二聚体的跨膜糖蛋白质,可以调节肿瘤细胞在多种细胞外基质蛋白中的粘附和迁移,在被激活的内皮细胞中有较高的表达,并在新生血管生成过程中发挥优势。
整合素αVβ3在细胞外的信号传入细胞内调节细胞生长、改变细胞形态、影响细胞运动, 并在肿瘤侵袭和转移的过程中起重要作用.整合素αVβ3是特异性表达在血管内皮细胞表面的粘附因子。
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