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Rabbit Anti-Syndecan-1/FITC Conjugated antibody
background:
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HISLV1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008].
Function:
Cell surface proteoglycan that bears both heparin sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.
Subunit:
Interacts with CDCP1.
Subcellular Location:
Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.
Post-translational modifications:
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Similarity:
Belongs to the syndecan proteoglycan family.
Database links:
Entrez Gene: 6382 Human
Entrez Gene: 20969 Mouse
Entrez Gene: 25216 Rat
Omim: 186355 Human
SwissProt: P18827 Human
SwissProt: P18828 Mouse
SwissProt: P26260 Rat
Unigene: 22927 Human
Unigene: 665958 Human
Unigene: 2580 Mouse
Unigene: 11176 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Syndecan1(CD138)属于Syndecans基因家族,该家族是一类细胞表面跨膜蛋白多糖 ,是膜表面粘附受体 ,参与细胞-细胞外基质之间的粘附。
CD138表达于上皮细胞、胚胎间质细胞、血管平滑肌细胞、内皮细胞和神经细胞基底膜。Syndecan-1与恶性肿瘤的发生发展、浸润及转移有关,着色于胞浆和胞膜.
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