background:
Protein-kinase-SLCrelated kinases (PRKs) are part of the lipid-regulated protein kinases (PKC) which also include liver PAK & PKN. Human PRK1 and PRK2 share structurally similar catalytic domains, but less similar N-terminal regulatory regions suggesting different regulatory domain functions. PRK1 and PRK2, as well as a third member of this family, PRK3, show distinct patterns of expression in adult tissues. Additionally, the serine-threonine kinase PRK2 can be specifically cleaved by caspase-3 (and/or caspase-3-like subfamily members) during apoptosis
Function:
Involved in chromatin organization.
Subunit:
Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA.
Subcellular Location:
Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
Tissue Specificity:
Ubiquitous. Expressed at relatively high levels.
Post-translational modifications:
Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.
DISEASE:
Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene.
Similarity:
Contains 1 SAP domain.
Database links:
Entrez Gene: 5586 Human
Entrez Gene: 109333 Mouse
Entrez Gene: 207122 Rat
Omim: 602549 Human
SwissProt: Q16513 Human
SwissProt: Q8BWW9 Mouse
SwissProt: O08874 Rat
Unigene: 88833 Human
Unigene: 244236 Mouse
Unigene: 30325 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
激酶和磷酸酶
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