Rabbit Anti-CYP19/FITC Conjugated antibody

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ARO 1; ARO; ARO1; ARO1; Aromatase; CP19A_HUMAN; CPV; CPV1; CYAR; CYP19; CYP19A1; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Cytochrome P450 family 19 subfamily A polypeptide 1; Cytochrome P450, family 19, subfamily A, polypeptide 1; Cytochrome P4

Cat:

SL1292R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human CYP19

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

Flow-Cyt=1:50-200ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

58kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. Belongs to the cytochrome P450 family.

Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Subcellular Location:
Membrane; Peripheral membrane protein.

Tissue Specificity:
Brain, placenta and gonads.

DISEASE:
Defects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:139300]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity.
Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:613546]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.

Similarity:
Belongs to the cytochrome P450 family.

Database links:

Entrez Gene: 1588 Human

Entrez Gene: 13075 Mouse

Entrez Gene: 25147 Rat

Omim: 107910 Human

SwissProt: P11511 Human

SwissProt: P28649 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

芳香化酶基因(CYP19)编码的芳香化酶是催化雄激素向雌激素转化的关键酶,CYP19的变异可使芳香化酶活性改变,导致雌激素水平的改变,从而使乳腺癌易感性发生改变,也可能影响到乳腺癌内分泌治疗的敏感性。
目前关于CYP19基因多态性与乳腺癌之间的关系仍存在争论,尚需深入研究以明确芳香化酶的基因多态性在乳腺癌发生中的作用,以及该基因多态性对芳香化酶功能的影响。

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