Rabbit Anti-ING1/FITC Conjugated antibody

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ING1_HUMAN; Inhibitor of growth protein 1; inhibitor of growth gene 1; Growth inhibitor ING 1; Growth inhibitor ING1; Growth inhibitory protein ING 1; Growth inhibitory protein ING1; Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds; ING 1;

Cat:

SL1291R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human inhibitor of growth gene 1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

46kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].

Function:
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Subcellular Location:
Nucleus.

Tissue Specificity:
Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.

DISEASE:
Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.

Similarity:
Belongs to the ING family.
Contains 1 PHD-type zinc finger.

Database links:

Entrez Gene: 3621 Human

Entrez Gene: 26356 Mouse

Entrez Gene: 306626 Rat

GenBank: NP_937862 Human

Omim: 601566 Human

SwissProt: Q9UK53 Human

SwissProt: Q9QXV3 Mouse

Unigene: 46700 Human

Unigene: 508725 Human

Unigene: 25709 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

肿瘤的发生是一个多基因参与,多步骤发生的复杂过程，抑癌基因的功能失活与癌基因的激活为其主要原因之一。 ING1基因是近期发现的抑癌基因，研究发现，它的过表达可抑制细胞生长、增殖,促进细胞凋亡，它的低表达与肿瘤的发生、发展有关。ING1正常时定位于胞核，发挥其诱导凋亡和调控细胞周期的作用，当其易位于胞质时上述作用逐步减弱或消失，在肿瘤发生时，多位于胞浆。

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