background:
This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. [provided by RefSeq, Jul 2008]
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Highly expressed in testis.
Similarity:
Belongs to the chemokine-like factor family.
Contains 1 MARVEL domain.
Database links:
Entrez Gene: 520499 Cow
Entrez Gene: 146225 Human
Omim: 607885 Human
SwissProt: Q8TAZ6 Human
Unigene: 195685 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CKLFSF2蛋白特异性的表达于减数分裂及分裂后的各级生精细胞中,它定位于高尔基体周围的内质网上,而且和生精功能损害密切相关。
CKLFSF2可能在减数分裂及精子生成的过程中发挥重要作用,并可能与内质网的囊泡转运和膜定位过程相关联。
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