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Rabbit Anti-PLEKHO1/FITC Conjugated antibody
background:
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2(CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Function:
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Subunit:
Heterodimer or homodimer.
Subcellular Location:
Cell membrane. Nucleus. Cytoplasm. Predominantly localized to the plasma membrane. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells.
Tissue Specificity:
Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cancer cell lines such as MOLT-4, HEK293 and Jurkat cells.
Post-translational modifications:
SLCterminal fragments could be released during apoptosis via caspase-3-dependent cleavage.
Similarity:
Contains 1 PH domain.
Database links:
Entrez Gene: 51177 Human
Entrez Gene: 67220 Mouse
Entrez Gene: 310674 Rat
Omim: 608335 Human
SwissProt: Q53GL0 Human
SwissProt: Q9JIY0 Mouse
SwissProt: Q5BJM5 Rat
Unigene: 438824 Human
Unigene: 458147 Mouse
Unigene: 21037 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
酪蛋白激酶2相互作用蛋白1是近年来发现的一种重要分子，它通过与其他分子的相互作用在许多细胞行为中都发挥着重要的作用。 CKIP-1还具有促进细胞凋亡的作用。CKIP-1可以与caspase-3形成正反馈环，增强肿瘤细胞的凋亡。
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