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Rabbit Anti-CCN1/FITC Conjugated antibody
background:
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
Function:
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Subcellular Location:
Secreted.
Similarity:
Belongs to the CCN family.
Contains 1 CTCK (SLCterminal cystine knot-like) domain.
Contains 1 IGFBP N-terminal domain.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.
Database links:
Entrez Gene: 3491 Human
Entrez Gene: 16007 Mouse
Entrez Gene: 83476 Rat
Entrez Gene: 508941 Cow
Omim: 602369 Human
SwissProt: O00622 Human
SwissProt: P11686 Mouse
SwissProt: Q9ES72 Rat
Unigene: 8867 Human
Unigene: 1231 Mouse
Unigene: 22129 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
高半胱氨酸蛋白61是富含半胱氨酸的分泌性肝素连接蛋白,是CCN家族成员之一,属于生长因子诱导的即刻早期基因,有明显的促有丝分裂和趋化活性作用,有诱导成纤维细胞增殖和分泌细胞外基质等功能,可促进细胞增殖、迁移、黏附、分化和细胞外基质(ECM)合成的作用,在新生血管及肿瘤形成过程中起着重要作用。
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