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Rabbit Anti-CD166/FITC Conjugated antibody
background:
CD166 is a member of the Ig superfamily and is expressed on activated T-cells, B cells and other cells including thymic epithelial cells, fibroblasts, keratinocytes and neurons. CD6 has been identified as a receptor for CD166.
The expression of CD166 is up-regulated in low-grade prostate tumors and down-regulated in high-grade tumors; may play role in progression of prostate cancer.
Function:
Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and hemophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.
Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 Ig-like SLVtype (immunoglobulin-like) domains.
Database links:
Entrez Gene: 214 Human
Entrez Gene: 11658 Mouse
Entrez Gene: 79559 Rat
Omim: 601662 Human
SwissProt: Q13740 Human
SwissProt: Q61490 Mouse
SwissProt: O35112 Rat
Unigene: 591293 Human
Unigene: 288282 Mouse
Unigene: 5789 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ALCAM/CD166是免疫球蛋白超家族的成员,对多种肿瘤生长和转移相关的肿瘤细胞特性具有调节作用,ALCAM/CD166在乳腺癌、前列腺癌、食道癌、结肠癌及恶性黑色素瘤等肿瘤都有一定的表达，尤以结肠、直肠癌表达显著。
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