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Rabbit Anti-WNT5A/FITC Conjugated antibody
background:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
Subunit:
Interacts with PORCN. Interacts with WLS.
Subcellular Location:
Secreted, extracellular space, extracellular matrix.
Tissue Specificity:
Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).
Post-translational modifications:
Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding.
Glycosylation is necessary for secretion but not for activity.
DISEASE:
Defects in WNT5A are the cause of Robinow syndrome autosomal dominant (DRS) [MIM:36700]. A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases.
Similarity:
Belongs to the Wnt family.
Database links:
Entrez Gene: 7474 Human
Entrez Gene: 530005 Cow
Entrez Gene: 22418 Mouse
Entrez Gene: 64566 Rat
Omim: 164975 Human
SwissProt: P41221 Human
SwissProt: P22725 Mouse
SwissProt: Q5PY99 Rat
SwissProt: Q9QXQ7 Rat
Unigene: 643085 Human
Unigene: 287544 Mouse
Unigene: 48749 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
WNT5A蛋白属于Wnt原癌基因家族中的一种。Wnt5a与肿瘤、发生、转移有关。
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