Rabbit Anti-VIP/FITC Conjugated antibody

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Vasoactive Intestinal peptide; MGC13587; Peptide histidine methioninamide 27; PHM 27; PHM27; PHV42; VIP peptides precursor; PHI; Peptide Histidine Isoleucine; Vasoactive intestinal peptide; VIP_HUMAN.

Cat:

SL0077R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Chicken,Dog,Pig,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human VIP

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

3.3/18kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Growth Factor and Hormones
VIP(Vasoactive Intestinal peptide) is a 28-amino acid peptide structurally related tosecretin. It was originally isolated from intestinal extracts and shown to be a potent vasodilator. Subsequent work demonstrated that VIP is very widely distributed in the peripheral and central nervous systems, and probably should not be considered a true GI hormone. A huge number of biological effects have been attributed to VIP. With respect to the digestive system, VIP seems to induce smooth muscle relaxation (lower esophageal sphincter, stomach, gallbladder), stimulate secretion of water into pancreatic juice and bile, and cause inhibition of gastric acid secretion and absorption from the intestinal lumen.

Function:
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHM and PHV also cause vasodilation.

Subcellular Location:
Secreted.

Similarity:
Belongs to the glucagon family.

Database links:

Entrez Gene: 7432 Human

Entrez Gene: 22353 Mouse

Entrez Gene: 117064 Rat

Omim: 19264 Human

SwissProt: P01282 Human

SwissProt: P32648 Mouse

SwissProt: P01283 Rat

Unigene: 53973 Human

Unigene: 98916 Mouse

Unigene: 18675 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

VIP是一个广泛分布于中枢神经系统和周围神经系统的神经肽，他有较强的血管舒张作用、支气管扩张作用、平滑肌松弛作用，具有很多免疫系统细胞的活性，是一个促分裂剂。
近年来研究表明，VIP也是一种生长因子,它对多种恶性肿瘤的发生、发展、增殖和分化起重要的促进作用，血管活性肠肽的神经保护作用受到来自胶质细胞的活性依赖的神经营养因子释放的调节。VIP和PACAP有很高的同源性。

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