background:
VCAM1 is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells.
Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Subunit:
Binds to ECMSLVD capsid proteins and acts as a receptor for this virus.
Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity:
Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.
Similarity:
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Database links:
Entrez Gene: 7412 Human
Entrez Gene: 22329 Mouse
Entrez Gene: 25361 Rat
GenBank: NP_001069.1 Human
GenBank: NP_001186763.1 Human
Omim: 192225 Human
SwissProt: P1964 Human
SwissProt: P29533 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞粘附蛋白（Call Adhesion Protein）
CD106是一种膜相关蛋白，分布于血管内皮及其周围的淋巴细胞、单核细胞、嗜酸性粒细胞和中性粒细胞。Anti-VCAM-1主要用于各种组织中血管内皮的检测。
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