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Rabbit Anti-CIDEB/FITC Conjugated antibody
background:
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as an inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A and CIDE B were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE B induces apoptosis, which is inhibited by DFF45. CIDE B is a DFF45 inhibitable effector that promotes cell death and DNA fragmentation. CIDE B is expressed mainly in liver and small intestine and at lower levels in spleen, colon, kidney, peripheral blood lymphocytes, and bone marrow.
Function:
Activates apoptosis.
Subunit:
Inhibited by DFFB. Interacts with DFFA and DFFB.
Tissue Specificity:
Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen.
Similarity:
Contains 1 CIDE-N domain.
Database links:
Entrez Gene: 27141 Human
Entrez Gene: 12684 Mouse
Entrez Gene: 364388 Rat
Omim: 604441 Human
SwissProt: Q546V8 Human
SwissProt: Q9UHD4 Human
SwissProt: O70303 Mouse
Unigene: 642693 Human
Unigene: 696081 Human
Unigene: 708040 Human
Unigene: 466766 Mouse
Unigene: 204016 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CIDEB是在细胞凋亡的过程中诱导分泌的一种蛋白,在棕色脂肪组织,肝脏和肾脏中发现有高水平的DFF45-like effector--DFF45样效应子b蛋白,简称cideb。CIDEB具有调控脂质代谢的作用。
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