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Rabbit Anti-TRADD/FITC Conjugated antibody
background:
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Function:
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Subunit:
Interacts with TRIP12. Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP.
Subcellular Location:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus.
Tissue Specificity:
Found in all examined tissues.
Similarity:
Contains 1 death domain.
Database links:
Entrez Gene: 8717 Human
Entrez Gene: 71609 Mouse
Entrez Gene: 246756 Rat
Omim: 603500 Human
SwissProt: Q15628 Human
SwissProt: Q3U0V2 Mouse
Unigene: 92996 Human
Unigene: 264255 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TRADD在凋亡信号传导中起重要作用,近年来多用于研究其在肿瘤中的作用,探讨TRADD在促细胞凋亡和促细胞存活的机制如何控制,将有利于我们了解肿瘤发病机理。
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