Rabbit Anti-TGF beta 2 Propeptide/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-TGF beta 2 Propeptide/FITC Conjugated antibody

BSC 1 cell growth inhibitor; BSC1 cell growth inhibitor; Cetermin; G TSF; Glioblastoma derived T cell suppressor; Glioblastoma derived T cell suppressor factor; GTSF; MGC116892; Polyergin; TGF B2; TGF beta2; TGFB 2; TGFB2; Transforming growth factor beta

Cat:

SL0100R-FITC

Species Reactivity：

Human,Mouse,(predicted: Rat,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human TGF-beta 2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

12/45kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Transforming Growth Factor (TGF) betas mediate many cell to cell interactions that occur during embryonic development. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.
The TGF beta polypeptides are multifunctional; capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed, as well as nonneoplastic tissues, release transforming growth factors; and essentially all mammalian cells possess a specific TGF receptor. The multi modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide. TGF beta 1, TGF beta 2, and TGF beta 1.2 appear to be equivalent in biological activity, although there does appear to be differences in binding to certain types of receptors. TGF beta 2 is produced by many cell types and has been found in the highest concentration in porcine platelets and mammalian bone. Latent TGF beta 2 is the prominent isoform found in body fluids such as amniotic fluid, breast milk, and the aqueous and vitreous humor of the eye.

Function:
TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

Subunit:
Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN.

Subcellular Location:
Secreted.

Similarity:
Belongs to the TGF-beta family.

Database links:

Entrez Gene: 7042 Human

Entrez Gene: 2368 Mouse

Omim: 190220 Human

SwissProt: P21214 Cow

SwissProt: P61812 Human

SwissProt: P27090 Mouse

Unigene: 133379 Human

Unigene: 18213 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生长因子和激素（ Growth Factor and Hormones）
TGF是一种多效生长因子,对上皮细胞增殖有潜在抑制作用,可抑制肿瘤生长用于许多恶性肿瘤如:胃癌、肺癌、膀胱癌、肾癌、前列腺癌、结肠癌等多种恶性肿瘤的研究。此抗体是TGFβ2 特异性抗体，与TGF-β1和TGF-β3没有交叉反应。

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