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Rabbit Anti-SELS/FITC Conjugated antibody
background:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Function:
Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
Subunit:
Interacts with DERL1 and VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm (By similarity).
Similarity:
Belongs to the selenoprotein S family.
Database links:
Entrez Gene: 55829 Human
Entrez Gene: 22015 Mouse
Entrez Gene: 286900 Rat
Omim: 607918 Human
SwissProt: Q9BQE4 Human
SwissProt: Q9BCZ4 Mouse
SwissProt: Q8VHV8 Rat
Unigene: 32148 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
炎症负调控因子蛋白-Tanis蛋白在肝脏、脂肪和骨骼肌等组织都有其基因表达，可能作为血清淀粉样蛋白A受体参与糖代谢，并与胰岛素抵抗、Ⅱ型糖尿病的发生与发展密切相关。Tanis在胰岛素抵抗、Ⅱ型糖尿病和代谢综合征动物模型的肝脏中表达水平与血糖及胰岛素浓度呈负相关，与血浆甘油三酯浓度呈正相关。Tanis的基因表达在禁食24 h后的糖尿病动物模型中显著增加，说明受葡萄糖调节。从目前的研究资料看，Tanis有可能成为治疗胰岛素抵抗、Ⅱ型糖尿病的新靶点而受到重视。
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