Home
>
Product
>
Antibody
>
Rabbit Anti-STAT6/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
Subunit:
Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its SLCterminal LXXLL motif.
Subcellular Location:
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Post-translational modifications:
Tyrosine phosphorylated following stimulation by IL-4 and IL-3.
Similarity:
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.
Database links:
Entrez Gene: 6778 Human
Entrez Gene: 20852 Mouse
Entrez Gene: 362896 Rat
Omim: 601512 Human
SwissProt: P42226 Human
SwissProt: P52633 Mouse
Unigene: 524518 Human
Unigene: 121721 Mouse
Unigene: 6176 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
信息转导和转录激活因子-6(signal transducer and activator of transcription-6,STAT6)是信号转导和转录激活因子(STAT)家族的一员,是一种94kD的蛋白质。它通过JAK-STAT信号转导途径介导细胞因子IL-3、IL-4及IL-13诱导的基因表达,特别是在促进IL-4诱导的MHCⅡ类抗原及免疫球蛋白受体等的表达及Th2细胞和淋巴细胞的发育上发挥了重要的作用。
|
|