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Rabbit Anti-PLGF/FITC Conjugated antibody
background:
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Function:
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.
Subunit:
Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF.
Subcellular Location:
Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
Tissue Specificity:
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the PDGF/VEGF growth factor family.
Database links:
Entrez Gene: 5228 Human
Entrez Gene: 18654 Mouse
Entrez Gene: 94203 Rat
Omim: 601121 Human
SwissProt: P49763 Human
SwissProt: P49764 Mouse
SwissProt: Q63434 Rat
Unigene: 252820 Human
Unigene: 969 Mouse
Unigene: 6960 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PLGF胎盘生长因子是血管生长因子家族成员之一（又称：胎盘型血管内皮细胞生长因子），是动脉粥样硬化斑块不稳定的主要炎性激活物，因此它可作为ACS患者风险预测的生物学标志物.尿胎盘生长因子水平可预测先兆子痫危险.研究人员发现，在疾病发作前的6到8周，先兆子痫患者尿液中的胎盘生长因子水平急剧下降,这种新的尿检方法使提前1到2个月预测先兆子痫成为可能。亦有研究人员正在从事胎盘生长因子与肺气肿，胃癌，肠癌等方面的研究。
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