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Rabbit Anti-PDGF-A/FITC Conjugated antibody
background:
Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heal the wound. Antiparallel disulfide-linked dimer of nonidentical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. The long form contains a basic insert which acts as a cell retention signal. A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. It belongs to the PDGF/VEGF growth factor family.
Function:
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB.
Subunit:
Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.
Subcellular Location:
Secreted. Note=Released by platelets upon wounding.
Tissue Specificity:
Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
Similarity:
Belongs to the PDGF/VEGF growth factor family.
Database links:
Entrez Gene: 5154 Human
Omim: 173430 Human
SwissProt: P04085 Human
Unigene: 535898 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PDGF-A(platelet-dirived growth factor-A)是一种碱性蛋白,pdgf促进细胞分裂、增值同时,可诱导c-fos、c-myc等蛋白表达增强。
主要作用:参与组织和血管修复、促进平滑肌细胞、成纤维细胞迅速增值。分子量为28-35kDa,分为两个亚基(A、B链)通过二硫键结合而成的两条多肽链的异二聚体。最新研究发现了PDGF家族两种新的基因PDGF-C、PDGF-D。
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