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Rabbit Anti-Urokinase/FITC Conjugated antibody
background:
Urokinase is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in the Urokinase gene may be associated with late onset Alzheimer disease and also with decreased affinity for fibrin binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg Val bond in plasminogen. The proprotein is cleaved at a Lys Ile bond by plasmin to form a two chain derivative in which a single disulfide bond connects the amino terminal A chain to the catalytically active, carboxy terminal B chain. This two chain derivative is also called HMW uPA (high molecular weight uPA). HMW uPA can be further processed into LMW uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino terminal fragment. LMW uPA is proteolytically active but does not bind to the uPA receptor.
Function:
Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in the prostate gland and prostate cancers.
Post-translational modifications:
Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
Similarity:
Belongs to the peptidase S1 family.
Contains 1 EGF-like domain.
Contains 1 kringle domain.
Contains 1 peptidase S1 domain.
Database links:
Entrez Gene: 5328 Human
Entrez Gene: 18792 Mouse
Entrez Gene: 25619 Rat
Omim: 191168 Human
SwissProt: P00749 Human
SwissProt: P06869 Mouse
SwissProt: P29598 Rat
Unigene: 77274 Human
Unigene: 4183 Mouse
Unigene: 6064 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
尿激酶型纤溶酶激活因子;是一种多效细胞因子，参与多种病理生理过程；uPA系统可通过调节纤溶酶的活性降解p淀粉样蛋白;是一种丝氨酸蛋白酶，将血浆酶原转化成血浆酶（纤维蛋白溶酶）。
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