Home
>
Product
>
Antibody
>
Rabbit Anti-Thrombin receptor/ PAR1/FITC Conjugated antibody
background:
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]
Function:
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Platelets and vascular endothelial cells.
Post-translational modifications:
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 2149 Human
Omim: 187930 Human
SwissProt: P56488 Baboon
SwissProt: P25116 Human
Unigene: 482562 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PAR蛋白全称为蛋白酶体活化受体(Protease-activated receptors),又称:凝血酶受体(Thrombin Receptor)是独立家族的G蛋白偶联受体, 研究认为与炎症,实体肿瘤等密切相关。
PAR1蛋白是乳腺癌细胞侵润和迁移的必需因子,它是作为基质金属蛋白酶体1(MMP-1)的受体关键性作用,这一研究结果为研制新的抗癌药物提供新的靶点。
|
|