background:
Platelet-activating factor, a compound that reduces inflammation by increasing permeability of blood vessels and contracting various involuntary muscles such as those in airways. It is a phospholipid with a wide range of proinflammatory actions, is immediately degraded and inactivated in vivo by PAF acetylhydrolase.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
血小板活化因子（platelet-activating factor，PAF）是一种内源性具有生物活性的磷脂。由中性粒细胞、血小板、肥大细胞、内皮细胞和巨噬细胞产生。除早期发现它有强烈引起血小板聚集和脱颗粒作用外，近年来的研究发现它还具有广泛的生物活性，作为一种独特的细胞因子参与体内多种生理、病理过程，包括激活中性粒细胞，使其聚集、趋化、释放氧自由基和白三烯，抑制T细胞增殖，刺激B细胞合成IgG和IgE，抑制心肌收缩力，增加血管通透性，引起体循环血压下降和肺动脉高压等。由于它具有广泛的高强度的生物活性，故PAF被认为是与过敏反应有关的关键性介质之一。
|
|
