Rabbit Anti-PADI4/FITC Conjugated antibody

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EC 3.5.3.15; HL 60 PAD; HL-60 PAD; PAD 4; PAD; PADI 4; PADI 5; PADI H protein; PADI5; PDI 4; PDI 5; PDI4; PDI5; Padi4; PADI4_HUMAN; Peptidyl arginine deiminase type IV; Peptidyl arginine deiminase type V; Peptidylarginine deiminase IV; Protein arginine de

Cat:

SL0318R-FITC

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human PADI4

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

74kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
PADI4 (peptidyl arginine deiminase, type IV) catalyzes the deimination of arginine residues of proteins. Down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. subcellular location at cytoplasmic granules. Belongs to the protein arginine deiminase family. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.

Function:
Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.

Subcellular Location:
Cytoplasm. Nucleus. Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils and neutrophils.

Tissue Specificity:
Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes.

Post-translational modifications:
Autocitrullination at Arg-372 and Arg-374 inactivates the enzyme.

DISEASE:
Rheumatoid arthritis (RA) [MIM:36300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note=The gene represented in this entry may be involved in disease pathogenesis. It could play a role in increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.

Similarity:
Belongs to the protein arginine deiminase family.

Database links:

Entrez Gene: 23569 Human

Omim: 605347 Human

SwissProt: Q9UM07 Human

Unigene: 522969 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PADI4或称PAD4 (Protein-arginine deiminase type IV) 是关节炎相关基因，分子量为：74kDa。有学者认为：PADI4也称Ⅳ型肽基精氨酸脱氨酶，该蛋白与关节炎的发生关系密切。PADI4 基因能够合成一种酶，将精氨酸变为桔霉素，当含桔霉素蛋白质的数量超过正常标准后，人体血液中便会出现攻击含桔霉素的蛋白质的抗体，这种机理是导致关节炎的重要因素之一。

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