Rabbit Anti-PACAP receptor/FITC Conjugated antibody

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ADCYAP1 R1; ADCYAP1R 1; PACAP-R1; adenylate cyclase activating polypeptide 1 (pituitary) receptor type 1; PAC 1; PAC1; PAC1R; PACAP R 1; PACAP1 R; PACAPR; PACAPRI; Pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop; Pituitary aden

Cat:

SL0198R-FITC

Species Reactivity：

Mouse,Rat,(predicted: Human,Chicken,Dog,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from the middle of human PACAP R1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

51kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide belonging to the vasoactive intestinal polypeptide/glucagon/ secretin family. It is widely distributed in the body, and a variety of biological actions have been reported. Recent studies have shown that there is a family of PACAP receptors (PACAPRs), and two members of this family have been identified. This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (By similarity). Belongs to the G-protein coupled receptor 2 family.

Function:
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

Subunit:
Interacts (via N-terminal extracellular domain) with ADCYAP1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.

Similarity:
Belongs to the G-protein coupled receptor 2 family.

Database links:

Entrez Gene: 117 Human

Entrez Gene: 319095 Cow

Entrez Gene: 11517 Mouse

Entrez Gene: 24167 Rat

Omim: 102981 Human

SwissProt: Q29627 Cow

SwissProt: P41586 Human

SwissProt: P70205 Mouse

SwissProt: P32215 Rat

Unigene: 377783 Human

Unigene: 44245 Mouse

Unigene: 81688 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生长因子和激素（ Growth Factor and Hormones）
PACAP 受体分为两个亚型，PACAP-1型受体对PACAP是特异性的，与PACAP的亲和力比VIP高100-1000倍，PACAP-II型受体与PACAP和VIP的亲和力相似，对二者无选择性。此抗体即为前者。

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