Rabbit Anti-PACAP-27/38/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-PACAP-27/38/FITC Conjugated antibody

Adenylate Cyclase Activating Polypeptide 1 (Pituitary); Prepro-PACAP; PACAP; Pituitary Adenylate Cyclase Activating Polypeptide; PRP-48; PACAP27; PACAP38; ADCYAP1; PACA_HUMAN;

Cat:

SL0190R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human PACAP-27/38

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

19kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Function:
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).

Subunit:
Interacts with ADCYAP1R1 (via N-terminal extracellular domain).

Subcellular Location:
Extracellular region or secreted

Similarity:
Belongs to the glucagon family.

Database links:

Entrez Gene: 116 Human

Entrez Gene: 11516 Mouse

Entrez Gene: 414283 Pig

Entrez Gene: 24166 Rat

Omim: 10596 Human

SwissProt: P18509 Human

SwissProt: O70176 Mouse

SwissProt: P41535 Pig

SwissProt: P13589 Rat

Unigene: 531719 Human

Unigene: 727476 Human

Unigene: 3407 Mouse

Unigene: 37400 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

腺苷酸环化酶激活肽是一种可激活垂体腺苷酸环化酶的多肽，有PACAP-27和 PACAP-38两种形式，他们共同具有N端27个氨基酸，属于PACAP/glucagon超级家族。在中枢神经系统分布广泛，其中以下丘脑含量最高。

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