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Rabbit Anti-osteopontin/FITC Conjugated antibody
background:
Osteopontin is the principal phosphorylated glycoprotein of bone and is expressed in a limited number of other tissues including dentine.
Osteopontin is produced by osteoblasts under stimulation by calcitriol and binds tightly to hydroxyapatite. It is also involved in the anchoring of osteoclasts to the mineral of bone matrix via the vitronectin receptor, which has specificity for osteopontin. Osteopontin is overexpressed in a variety of cancers, including lung, breast, colorectal, stomach, ovarian, melanoma and mesothelioma.
Function:
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity).
Subunit:
Ligand for integrin alpha-V/beta-3.
Subcellular Location:
Secreted.
Tissue Specificity:
Bone. Found in plasma.
Similarity:
Belongs to the osteopontin family.
Database links:
Entrez Gene: 6696 Human
Entrez Gene: 20750 Mouse
Entrez Gene: 25353 Rat
Omim: 166490 Human
SwissProt: P10451 Human
SwissProt: P10923 Mouse
SwissProt: P08721 Rat
Unigene: 313 Human
Unigene: 288474 Mouse
Unigene: 8871 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
信号传导(Signaling Intermediates)
骨桥蛋白(osteopontin,OPN)是一种含精氨酸—甘氨酸—天冬氨酸(Arg-Gly-Asp,RGD)的分泌型糖基化磷蛋白,已归类于细胞外基质(extracellular matrix,ECM)蛋白。 OPN既是细胞因子,又是细胞黏附分子.又称:分泌性磷酸化蛋白质1
OPN最初是从骨组织分离的,而后在上皮细胞、胃肠道的分泌物、肾、甲状腺、睾丸以及一些肿瘤细胞里都陆续的发现了OPN的表达。在生殖方面,OPN在分泌期子宫内膜上皮细胞、侵袭的滋养细胞、蜕膜细胞中表达。
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