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Rabbit Anti-Nrf2/FITC Conjugated antibody
background:
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Function:
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Subunit:
Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.
Subcellular Location:
Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
Tissue Specificity:
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
Post-translational modifications:
Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.
Similarity:
Belongs to the bZIP family. CNC subfamily.
Contains 1 bZIP domain.
Database links:
Entrez Gene: 4780 Human
Omim: 600492 Human
SwissProt: Q16236 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录调节因子（Transcriptin Regulators）
核细胞系因子2相关因子Nrf2，是一种对氧化还原反应敏感的转录因子，可以通过正向促进基因的表达，来转录翻译产生一些抗氧化物，行使着异化解毒的酶类和药物的高效外排泵作用。
有学者认为：核因子2相关因子2蛋白在保护细胞免受环境毒性物质影响方面发挥着极其重要的作用，它指导某些基因促进细胞的防御工事，同时也刺激某些重要解毒酶对毒性物质，如黄曲霉素的解毒和排毒作用。
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